Maria Gutierrez-Arcelus

Former PhD Student

I have been part of the lab in short periods as an undergraduate student and as a rotation PhD student, and then officially started my PhD thesis in October 2010. During the thesis I have been mainly involved in the GenCord project in which we are studying the genetics and epigenetics of gene regulation in several cell-types. I have also fulfilled nascent transcriptome experiments in a trio family for the SYNERGIA project, which studies the heritability of several epigenetic marks and different levels of the transcriptome. I am interested in pursuing research on functional genomics and epigenomics to better understand gene regulation.


(most found in

Gutierrez-Arcelus M, Lappalainen T, Montgomery SB, Buil A, Ongen H, Yurovsky A, Bryois J, Giger T , Romano L, Planchon A, Falconnet E, Bielser D, Gagnebin M, Padioleau I, Borel C, Letourneau A, Makrythanasis P, Guipponi M, Gehrig C, Antonarakis SE, Dermitzakis ET. Passive and active DNA methylation and the interplay with genetic variation in gene regulation. eLife 2013;2:e00523
Research Highlight in Nature Review Genetics:

Dimas AS, Nica AC, Montgomery SB, Stranger BE, Raj T, Buil A, Giger T,
Lappalainen T, Gutierrez-Arcelus M; MuTHER Consortium, McCarthy MI, Dermitzakis ET. Sex-biased genetic effects on gene regulation in humans. Genome Res. 2012 Dec;22(12):2368-75

Stranger BE, Montgomery SB, Dimas AS, Parts L, Stegle O, Ingle CE, Sekowska M, Smith GD, Evans D, Gutierrez-Arcelus M, Price A, Raj T, Nisbett J, Nica AC, Beazley C, Durbin R, Deloukas P, Dermitzakis ET. Patterns of cis regulatory variation in diverse human populations. PLoS Genet. 2012 Apr;8(4):e1002639

Perry GH, Xue Y, Smith RS, Meyer WK, Calışkan M, Yanez-Cuna O, Lee AS,
Gutiérrez-Arcelus M, Ober C, Hollox EJ, Tyler-Smith C, Lee C. Evolutionary genetics of the human Rh blood group system. Hum Genet. 2012 Jul;131(7):1205-16.

Montgomery SB, Lappalainen T, Gutierrez-Arcelus M, Dermitzakis ET. Rare and common regulatory variation in population-scale sequenced human genomes. PLoS Genet. 2011 Jul;7(7):e1002144

Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U. Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell. 2010 Sep 17;142(6):943-53

Yang TP, Beazley C, Montgomery SB, Dimas AS, Gutierrez-Arcelus M, Stranger BE, Deloukas P, Dermitzakis ET. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics. 2010 Oct 1;26(19):2474-6

Montgomery SB, Sammeth M, Gutierrez-Arcelus M, Lach RP, Ingle C, Nisbett J, Guigo R, Dermitzakis ET. Transcriptome genetics using second generation sequencing in a Caucasian population. Nature. 2010 Apr 1;464(7289):773-7

Zepeda-Mendoza CJ, Lemus T, Yáñez O, García D, Valle-García D, Meza-Sosa KF, Gutierrez-Arcelus M, Márquez-Ortiz Y, Domínguez-Vidaña R, Gonzaga-Jauregui C, Flores M, Palacios R. Identical repeated backbone of the human genome. BMC Genomics. 2010 Jan 23;11:60

Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H, Ingle C, Beazley C, Gutierrez Arcelus M, Sekowska M, Gagnebin M, Nisbett J, Deloukas P, Dermitzakis ET, Antonarakis SE. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science. 2009 Sep 4;325(5945):1246-50

Richard SS, Gutierrez-Arcelus M, Tran CW, Park S, Couter CJ, Lee C, Structural Diversity of the Human Genome and Disease Susceptibility, ELS, John Wiley & Sons, July 2008

Lee AS, Gutierrez-Arcelus M, Perry GH, Vallender EJ, Johnson WE, Miller GM, Korbel JO, Lee C. Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies. Hum Mol Genet. 2008 Apr 15;17(8):1127-36

Flores M, Morales L, Gonzaga-Jauregui C, Domínguez-Vidaña R, Zepeda C, Yañez O, Gutierrez M, Lemus T, Valle D, Avila MC, Blanco D, Medina-Ruiz S, Meza K, Ayala E, García D, Bustos P, González V, Girard L, Tusie-Luna T, Dávila G, Palacios R. Recurrent DNA inversion rearrangements in the human genome. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6099-106